G1a PEDV vaccines have been widely used in some Asian countries, including South Korea, China, Japan, and Thailand. PEDV is now one of the most devastating porcine viruses that has emerged or re-emerged, presenting a significant threat to the worldwide pork industry. Then, the US prototype-like highly virulent G2b PEDV strains almost simultaneously invaded Asian countries, including South Korea, Taiwan, and Japan, resulting in the recurrence of a massive nationwide porcine epidemic diarrhea (PED) epidemic.
However, PEDV first emerged in the United States in 2013 and rapidly spread to adjacent North and South American countries, causing significant financial losses to their swine industries. PEDV was first identified in England and Belgium in the 1970s and has since been geographically restricted and problematic in Europe and Asia over the last three decades. Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus in the family Coronaviridae of the order Nidovirales, induces acute gastrointestinal symptoms characterized by dehydration, vomiting, diarrhea, and high mortality in newborn and suckling piglets. The results from our study suggest that any vaccination against PED is a useful strategy to control the disease regardless of the type of vaccine and administration route. live) or administration route (intramuscular vs. This analysis showed the efficacy of PED vaccines, and no significant differences in the efficacy depending on vaccine type (killed vs. A meta-analysis was performed on the 21 articles based on the fecal scores and survival rates. A total of 299 articles on the efficacy of PED vaccines were found online, and 21 articles were selected that fulfilled all the criteria. Therefore, we systematically reviewed published articles on PED and vaccines against the disease and performed a meta-analysis of vaccine efficacy based on the clinical signs, fecal score and survival rates.
Recent reports on PEDV variants make the vaccination for PEDV more confusing. Although the causative agent, the porcine epidemic diarrhea virus (PEDV), was identified about a half century ago, there is still much debate on the preventive measures against the disease, especially regarding the PED vaccine. Porcine epidemic diarrhea (PED) is a devastating disease that causes considerable economic damage to the global pig industry.